Center for Spatiotemporal Dynamics of Biological Response (SpatioBio)

In an era of super-aged societies, the decline in bone and muscle function among the elderly presents a critical issue, directly contributing to the shortening of healthy life expectancy and increasing societal burdens. The research center SpatioBio employs in vivo imaging technologies based on two-photon excitation microscopy and a range of biosensors to analyze the spatiotemporal dynamics of musculoskeletal tissues. Furthermore, by utilizing spaceflight-exposed mice and disuse syndrome models, we aim to comprehensively elucidate how physical activity and gravity influence biological systems, ultimately advancing the development of novel interventions—such as “exercise-mimetic drugs”—to restore and maintain musculoskeletal health.